We would like to show you a description here but the site won’t allow us. Drinking and consuming edibles confuses the liver because there’s too much to process which can be harmful to not just your liver. (Sometimes you have live rosin edibles and whatnot, but it is less common, I feel. Not so much smoking tolerance. if enough food is not eaten, the liver never gets the THC. I am a daily user and 10mg edible is enough for me. If eating edibles can give you liver problems, I died a while ago from cirrhosis. Accounts must be over three days old and must have both positive comment & post karma before they are allowed to post or comment in r/trees. For me, edibles seem to have a tolerance almost like acid. edibles are also, according to science, more chemically potent. New comments cannot be posted and votes cannot be cast. This is a known phenomenon for many people. It's much more likely the result of drinking alcohol or heavy exercise (if you've been doing a lot of that) or some other underlying medical condition Jun 10, 2024 · Are edibles bad for your liver? Considering the liver’s vital role in metabolizing substances, it’s important to explore the potential impact of edibles on this essential organ. Yes, the effectiveness of edibles partly depends on what quantities of certain enzymes are in your liver, and that depends on what genes you were born with. Smoking and vaping don't depend on your genes to the same extent that edibles do. There is massive variance in genetics for the enzymes needed to properly metabolize the drug in edible form, that is why you see a much larger difference from person to person with edibles than you do with smoking or vaping. The liver does process THC when ingested. Whereas smoking it’s like I’m really stoned but for only like 30 mins then the effects begin waring off quickly. Edibles can take longer to kick in compared to smoking or vaping, and the effects can be more intense. We describe the current understandings of how cannabis is metabolized in the liver and its potential interactions with other common drugs. I would think at higher doses things may start to vary since edibles are processed by the liver and not the usual blood brain barrier you may be used to from smoking. Some sources say it’s bad for your liver, others say It’s only bad if you have liver issues. Which makes it a more prolonged high and in my case, a more potent high. I hope that makes sense. They provide drastically different effects. Long story short, in April 2022 went in for a regular appointment and had high liver enzymes and low platelets… high cholesterol and type 2 diabetes. If this is true, does anyone know of the safest extraction method? That's a really interesting paper. This is one of the reasons why it can take some time to feel the effects of edibles. Also easier to tell if your product is legit if it is just weed, compared to fake edibles. I’m laying off the drink and thinking of just microdosing with gummies at night to help with sleep. Especially from the dispensary I'm a bigger guy, well versed in the THC realm. The liver is responsible for processing thc from edibles. When consumed orally d9-thc gets turned into some d11-thc by the liver. . I tried to dig further but I find a lot of confusing information. This active metabolite is particularly effective Now, if you smoke while eating edibles, your edibles may not feel like they're kicking in. Store infused drinks and nano/fast acting gummies could work better as they usually absorb as delta 9, while digested edibles are processed through the liver as hydroxy 11. If you don’t have the liver enzyme necessary to process edibles, the oil will probably only have full effect if you smoke it, but it might work somewhat for what is actually absorbed directly into the bloodstream. In fact, he says, using cannabis for pain in lieu of NSAIDs, such as ibuprofen, is better for your kidneys. My friend doesn't get high of them and ate like 500mg and got only a buzz If your liver has a large amount of the magic enzyme, the THC gets broken down before it has a chance to get you high. Does alcohol make edibles stronger? I know that combustion is inherently bad for a person but I keep getting mixed results on if edibles are bad for you. Its findings suggest that stimulating the CB1 & CB2 receptors allows the body to store more fat in the liver, whereas blocking that stimulation may reduce/block that fat storage mechanism. Also edibles are expensive. D11 is almost functional identical to D9, but D9 does not get into the blood stream. The go-to subreddit for anything and everything cannabis. Similarly, effect window can but up to 12 hours. I recommend a good quality vaporizer (cheap vaporizers don’t work well) because you can control the dose easier and you can choose if you want to get a little bit high or Edibles are great for lots of chronic health and pain issues, and the well made edibles at my favorite legal dispensary are some of the best and most consistent I've ever had. I would say there is very minimal risk to low and moderate dose edibles for most people. If you smoke or vape regularly, you’ll have a high tolerance and standard edibles (eg. Anytime you experiment, start low and go slow is the best advice. I have heard that with edibles the liver breaks it down into a different compound. First pass metabolism makes THC more potent by converting it into 11-OH-THC, which binds to the CB1 receptor with better affinity than THC. I've been taking Tylenol for the fever. When metabolized by the liver, alcohol produces acetaldehyde, a potent toxic that contributes to liver diseases such as cirrhosis and fatty liver disease. It's very unlikely that such a small edible dose (5mg) at such infrequent intervals (once or twice every other week) would cause elevated liver enzymes. Homemade alcohol tinctures may compete with drinks. It’s definitely something to consider and 1906 is doing research now on ways to make the product safe for consumption while still staying true to its brand Later some is metabolized through the liver but less. Please do not ask the moderators to approve your comment or post, as there are no exceptions to this rule. THC from edibles is no different, and it actually is metabolized by the liver. The question is specific to this circumstance. I was all "edibles are bullshit" and took a few hits from my bowl. I drank a LOT of beer and weighed roughly 275. I like to grow my own and I use that for edibles and vape the professional quality I buy. I am more sensitive to edibles than flower/concentrates as well. Now if Alcohol can damage your liver on its own based on concentration and we have a drug inhibiting an enzyme that processes it, we can say the risk of liver damage from Alcohol as well as general risks of Alcohol would be elevated in combination with such substances and that's an example of how they make be implicated in causing (or Nano edibles should still work for you because they bypass the liver and enter the bloodstream directly like smoking, no liver enzymes necessary. People hand me gummies to eat all the time, nothing. Haven't smoked in several months. Slow to take effect and lasting 6-12-24 hours this is a horse of a different color. I heard they are both processed by the liver. We also summarize how cannabis may exert various effects in chronic liver diseases (CLDs), especially in chronic hepatitis C virus (HCV) and fatty liver disease. Edibles get digested and processed through your liver, as opposed to through your lungs by smoking. Essentially i cant get high off edibles because my liver wont convert the THC to 11 Hydroxy. He made his own brownies old school way with a hero dose so to speak. When the liver processes alcohol, it’s metabolites are inactive and eventually metabolized into acetyl coA. It seems the most likely culprit is some difference with our digestive system. The lungs do not process the cannabinoids into the blood system. Jan 13, 2020 · Despite their appearance, cannabis edibles — sweet treats like gummies and chocolate bars infused with tetrahydrocannabinol (THC), the primary psychoactive component of marijuana — can be Chocolates and baked edibles seem to be better, but my baseline is 100mg to get any effect, which is just not cost effective. ELI5, if a person was able to free dive to the bottom of the ocean, they would reach a point where the crushing pressure would cause them to simply implode. They did blood tests on me and everything was good besides a slightly high liver reading. I’m trying to get high in the least damaging way possible lol Liver enzymes and ability to convert THC are a major factor. If it is from a dispensary, there's the possibility that you're a part of the subgroup of people who just don't properly metabolize THC through edibles. Edibles, the Delta-9 is metabolized in the Liver and small intestines by a couple of enzymes into the much stronger 11-hydroxy-THC. Different people's bodies have vastly different sensitivities to edibles, compared to smoking or vaping. But since it's metabolized differently that explains the different highs. shit even flower if i smoke it i get more of effect than edibles, I know why, prob cause of gut issues and my liver cant break it down. The cat in question was already getting daily oil (edible high CBD oil, not RSO/hash oil) for arthritis and appetite stimulation, and the fact that he has hyperthyroidism and this helps with that was just a lucky thing. Taking edibles with food helps with absorption. Nov 13, 2023 · The body processes the cannabinoids in edibles differently than when you smoke. It depends on your tolerance and if your body processes edibles well. Thats why you feel the way you do about it. The way it was explained to me was that when you eat something it’s destroyed by the stomach and filtered by the liver which does a pretty good job of filtering out THC, whereas the THC absorbed through your oral mucosa avoids the stomach and is instead filtered by the kidneys which doesn’t do as good of a job filtering out THC from the blood. Have tried just about every common edible on the market here in CO and have tried several homemade batches (including several of my own that obliterated friends) to no results. 10 mg) will feel extremely weak. Some day I'll probably attempt to make my own alcohol tincture w/ AVB and grain alcohol - sounds easy, I just have to remember to find and buy some Everclear. We do not allow posts asking if the brand of edibles you have or plan to have are legit, if the packaging looks legit, if edibles laced, asking for feedback on a brand, asking if the edibles are "real". If you have a fast metabolism, your liver could be detoxing the THC before you ever get really high from edibles. Just have to be careful with measuring and the strength. Eventually my chest got tight and I wound up throwing most of the food up and had shortness of breath and almost fainted a few times. i just found that out tonight, always thought it was subjective. "When you consume cannabis in an ingestible form, its THC is metabolized by the liver, which converts it to 11-hydroxy-THC. Your edible tolerance does not correlate to your smoking tolerance, because it is being processed by your liver, and different forms of THC are produced (look up “11-hydroxy THC, interesting stuff) 600 mg is way, way, way, way too much to start with. My gastrointestinalogist said to try the gummies if that helps with pain or in my case, sleep and anxiety. I've personally had home-made edibles that had 200 mg polm hash in them, so <100 mg THC, that kept me out of it for 24 hours. Cannabinoids do bind to fat molecules so eating can help give a longer effected period, but if a person has digestive or liver issues the edible maybe ineffective regardless of eating before the edible. when inhaled, some of the THC still goes thru the liver, but only about 10% and it's why there is a bump in the high 10-15 minutes in. I have buddies of a similar size that can't take half of what I ingest. Note this doesn't mean they'll help anyone else. The bowl hits and the edible hit me at the same time. The overwhelming majority of increases in enzymes were at the 20mg/kg dose in combination with Valproic acid, another known liver toxin. Normally this would be nbd, but in this case my liver enzyme count is already higher than normal, so I'm not supposed to drink or do anything too hard on the liver. If your liver enzymes are lower than usual, this could explain why you don’t feel anything from edibles as opposed to vaping/ smoking (these bypass first-pass metabolism and go directly into your bloodstream without getting metabolized in the gut. If so, did Nano THC edibles hit? If you are thinking "wait, wtf?! thats me! I dont get high off edibles at all Some people don't produce enough of the enzyme in their livers that metabolize THC into 11-OH-THC what makes edibles stronger and last longer than inhaling. With edibles, you gotta find how much you can handle. I don't smoke and am an occasional drinker. I just had a 1,500 mg of edibles I am a 6’5 220lb male, nonstop smoking and edibles for 10 months. I have eaten A LOT of weed, and have never truly gotten “stoned” I mean high potency dispensary tested stuff, 1g of distillate made into a cookie gave me just a light buzz on an empty stomach. You would need to eat 4-5g of pure CBD all at once to get the effects shown in the study. Crypto Ideally, you want to eat your edible followed by a meal. Alcohol on the other hand is active without metabolism. It’s got something to do with liver enzymes, and metabolism I believe. This also gives you a high more similar to flower, rather than the usual KO most people get from edibles. 1000-2000 mg servings, meant to work for people who have high tolerance (daily medical users). Get a 12oz bag of ghiradelli milk chocolate chips and a 1000 mg applicator of RSO of your choice. The home of edibles! A place to discuss edibles both legally purchased and made at home as well as recipes, techniques, and general discussions. To clarify, edibles are only "one of the most potent" methods if you're using a higher potency edible than whatever product you're comparing it to. Next time I mix a batch I'll try without, but edibles never worked for me before and since I started the enzymes, they have. When you have a good edible they can be a bit like smoking except it takes 2 hrs to kick in and might last 4-6 hrs with some more lingering effects. But oral ingestion is just too unpredictable for mixing with contra-indicated medication, when a much more consistent option is easily available. I was using my dab pen the past 2 days but now I have the dry cough part of Covid. Generally can take anywhere form and hour to 4 hours to take effect depending on your metabolism and tolerance. I read tincture is absorbed by the mucus membrane right into the blood unlike edibles are processed by the liver Archived post. You have to experiment. Edibles take a while to kick in, they usually give a stronger high, and the high lasts longer. Yeah. I had high liver enzymes in about 2000 when one of my clients gave me TB at work (social worker type job) and the meds I had to take required monthly liver tests. Okay so like i said ik this is probably a stupid question but since edibles are processed through your liver and not through your lungs directly into the bloodstream is it possible it could cause liver damage? i wanted to know because it’s usually the method i use and i eat them basically daily. Go for like, 20. Since then I’m down to 200 and liver enzymes are normal and everything else in check, except low platelets. So it's definitely possible, especially considering he probably hadn't done edibles before. However, I don’t want to bother if it’s gonna slow down the healing of the fatty liver. They will taste like ass. Liver gets busy processing the thc in edible into 11 hydroxy thc. Then eat a meal. I've heard that for edibles specifically, lecthin of some sort can help with absorbtion. Comfort at a 10 or 15mg dose of normal edibles lessens the risk. r/Mainetrees is the Reddit home to the legal Maine marijuana community: catering to medical patients, recreational enthusiasts, caregivers and dispensaries, independent cultivators and extractors, journalists, doctors, lawyers, and anyone else involved with cannabis in the 207. Can taking edibles alongside alcohol cause the liver to have trouble processing both at the same time? When I occasionally vape weed and have a few drinks I tend to get a nice little cross fade buzz going and wake up the next day with no real side effects (unless I had too much to drink, but normally getting cross faded actually causes me to drink less). Reply reply Old-Poetry-420 Feb 4, 2022 · What happens in the liver when you eat weed edibles? Unlike smoking, vaping, dabbing, or using tinctures and transdermal products, our bodies digest cannabis edibles, and our livers metabolize There is no data showing THC to be significantly liver toxic. Smoking is more of a head high and edibles is like full body + a more subtle head high id say. I’ve tried researching to find out if it’s ok for liver, thyroid, autonomic dysfunction or heart disease, but there’s nothing but conflicting info online. The liver treats unconverted D9 as waste. it is 3 times more psychoactive than delta 9. I use them daily as well. ) Edibles are eaten (obvi) and are absorbed through your liver. I have all blood work done twice a year due to a congenital cardiac issue and my blood work has been unaffected. Order the blue one with 126 squares. I detected no difference beyond the onset. If you've got some digestive or liver abnormality that causes you to get little effect from edibles, I'd bet you'll have the same problem with MCT tinctures. My liver. Here's where everyone goes back and forth. Hi, a friend of mine has liver failure. The thc is already bound to other fats and oils in the edible itself. Usually, not always. Normally when consuming edibles, the liver converts the delta-9 isomer of THC into delta-eleven THC. Reply Accomplished_Goal763 • Cannabis is very non-toxic and eating it is the least harmful method of ingestion. You can make any food a cannabis edible, from chocolate cookies to pepperoni pizza! In order to make cannabis edibles (like the delicious one pictured above), you will need cannabis (obviously!), an oven/heat for decarboxylation, butter, or oil to infuse your cannabis, and a delicious recipe to cook! We would like to show you a description here but the site won’t allow us. Here are some key points to keep in mind: Start with a Low Dose: If you're new to edibles or cannabis in general, start with a very low dose. Start with a low dose and don’t increase unless enough time has gone by (about 4 hours in some cases) to see if it has an Aug 1, 2021 · Once ingested, digested, and absorbed into the gastrointestinal system, the THC from edibles goes through a process known as first-pass metabolism in the liver. May not be the best option for you right now but good to know that its there later on once you get a feel for things. What they found out Inhalation is Delta-9-THC. But is it okay to take an edible at the same time as Tylenol? I know your liver processes both of them so I'm worried about that Edibles just tend to be inconsistent by nature and 1906 drops are advertised as being "nano-emulsified" THC, which means they are absorbed in a somewhat different way than normal edibles. As of lately I’ve been curious if edibles (regular,rosin, nano) have any impact on the liver (like alcohol does)? I’m sure there might be some other nerds like me who would want to learn more about this. The goal of it is to have "nano-sized" -aka smaller than normal THC droplets, so that it can be somewhat miscible with water. I’ve been searching and I haven’t been able to find a solid answer. Edibles are not hard on the kidneys,” says Grinspoon. Some people lack the digestive enzyme to break them down, so they never feel the effects of the edible. I'm sorry, but I tried nano-thc already and it doesn't hit me any harder than regular edibles, which don't hit me at all. What's low and slow for you is a decision only you can make. Cookies, brownies, etc. Since cannabis doesn’t cause cirrhosis or liver failure, edibles are also much safer for the liver, he adds. In your liver, the chemical transforms for delta-9 thc to 11-hydroxy thc. This means your peak high could come on several hours after taking it, leading to unpredictable results and timing. I take edible. When I tested nano edibles I used my minimum edible dose (20mg) where my max dose was 80mg. Edibles take longer to get high from and so people tend to overdose and get the cardiac and psychiatric effects of overdose. Every body is different. Edibles are usually measured by mg not g. Treat edibles like the Hallucinogenic they are or get your ass handed to you. smoking will get you high faster and shorter, edibles take and last longer. Eating first will guarantee that your liver is occupied within about 20 minutes, leaving most of the THC to be absorbed by the small intestine. But my liver specialist said edibles are toxic to the liver. Back when MMJ was the main deal in WA, I used to get really strong edibles for my ex-wife. They're processed by you liver so you could smoke more than Snoop Dogg and still get fucked up from a lower dose of edibles if you don't take them frequently. In your case you might want to start with either 2. I only eat edibles, tho. the high comes from when the food is digested and the THC9 goes to the liver where it gets converted to THC11. I am one such person. It’s possible they could get some function back. ) so I’d say find a source of less expensive bud for your edibles. it works thru the gastric track and the liver. I try to keep it to one CBD (high percentage) and THC (low percentage) lozenge a day, maybe a max of twice per week for pain management. The way a lot of dispensary edibles are dosed is with distillate. I saw things saying edibles can mess up your liver if used excessively. Most people with well functioning livers will find edibles have varying levels of effectiveness based on when and how they eat edibles. /r/Marijuana is an educational and informative subreddit focused on Marijuana, hemp, and the various cannabinoids. Fast acting and short lived. It seems to take into account the fact that when we blaze, we get the munchies, lol. That was like half an hour ago and my short term memory is kinda shot which kinda sucks because better call Saul is about to start. Edibles for me is a sold high that lasts for hours. If I haven't had an edible in a while I can take one and have a strong experience. Quick recipe for strong edibles. For me, it’s the opposite. EDIT: also keep in mind that the reason edibles take so long but hit so hard is that your digestive system has neurons (brain cells) in it too, but it takes a while for the edible to be digested to the point THC starts to get absorbed. I'm guessing probably not a big deal as I can't find any warnings against it. Nothing wrong with edibles except how unpractical they are for every day use. Fast Acting edibles are worth a try if regular edibles don’t seem to work! The nano emulsification allows the thc to bypass your liver and make its way straight to your bloodstream. Others say it can be good for your liver and blood pressure. So it's worse to smoke it, but the edibles go through your liver which is the main concern. For me, if I don't feel an edible kicking in, I smoke a few hits and the edible then kicks in, like it needed a kick start. The market is absolutely flooded and with the massive black market, we have no way to know. I wouldn’t do 1g. You can do the same with activated cannabis oil and put that in/on anything you eat and its an edible. My friend gave me a brownie. But in general, a full spectrum edible like the RSO gummies from Verano or RSO/FSO syringes will have better effect than an edible made with distillate. Apr 16, 2019 · A 2018 study looked at about 320,000 people with a history of both misusing alcohol and using cannabis to discover what effect, if any, using both drugs had on liver health. There are several known human genetic variations that cause differences in the efficiency of the liver processing of THC. We are dedicated to policy reform, news, advocacy, opinion, health, and discussion. In terms of effects though, I've read a couple of studies showing that cannabis can reverse liver damage caused by alcoholism. Feb 22, 2019 · Many Canadians use cannabis for medicinal and recreational purposes. Check the r/CannabisExtracts Rules and FAQ before posting. Your liver contains enzymes, but one specific one is called Cytochrome P450 (CYP) and having higher/lower CYP enzymes can alter the rate of metabolism and may even mean that THC isn’t metabolized at all. absolutely. I admit I don't drink as much water as I should. That’s because the liver will filter out THC from most edibles in varying levels of effectiveness. (Avb is also a decent edible, too, because it’s like weak weed. the rest will get broken up on the stomach and sent to the liver to be processed into 11-hydrox-thc. It seems to be helping. For instance a very large edible dose of 300mg is under 1 third of one gram. Sublingual methods (like lozenge edibles that you suck on, tinctures, etc) may also be a good option, as they dont get processed through the liver. I then was told i could have that CYP2C9 gene variant. Well, edibles take a lot of flower, but it doesn’t have to be high quality bud, average flower will do. I wouldn't even trust the real Willy Wonka, let alone people who steal his trademarks! The first time you make your own edibles, you realize all the commercially-available stuff isn't comparable. Don't know. 22-29 was standard. Is this from the particular extraction method leaving certain residues behind? Or is THC and/or CBD potentially harmful for our livers as well? I suspect it is due to extraction residues. People with really high metabolisms it tends to just flow right through you before your body can absorb the thc that gets you high. when its in the gastric track a little of it will dissolve into delta 9 thc, just like if you were to smoke it. But the effect is more impactful due to the presence of minor cannabinoids (Distillate in edibles is generally above 88% THC with virtually no minors and zero terpenes), and if they are produced properly, terpenes. No sales or product sourcing content permitted. For the past year or so i've really really got into edibles to save my lungs from smoke. So I tend to stay away from edibles as it's a "waste of money" for me. when you digest edibles, d9-thc is metabolized into 11-thc which is more potent and psychoactive than just the d9. I've read that edibles need to be processed in the liver before the body can absorb the THC and enjoy its effects. Type ‘silicon candy mold’. Initially I was using a flower pot and mighty + but I ended up just going full time with the edibles. lol I'm in the same boat re: edibles. GameStop Moderna Pfizer Johnson & Johnson AstraZeneca Walgreens Best Buy Novavax SpaceX Tesla. I had an IPA about 7% and decided to eat a 5mg edible to help with pain. With an oil tincture or edible, some might be absorbed before the digestive system but more will end up being processed by the liver and creating D11 THC which is way way stronger. I would suggest people with serious heart conditions to avoid high doses of edibles as mega doses like 800-2000mg can cause high heart rate temporarily. This is much more psychoactive than compared to THC9 (delta-9-tetrahydrocannabinol). Since they won't use the absolute best flower for edibles, it certainly was less than 200 mg THC. Anyway rambling. However, they also have some drawbacks, such as inconsistent effects, expensive pricing, bad taste, worries about negative health effects, and the question of why edibles don't get me high. My problem is I always eat an edible on an empty stomach. Edibles can be a safe and enjoyable way to consume cannabis when done responsibly. For instance eatting enough edibles and you can legitimately hallucinate, because of the liver processing. But they can’t smoke, always did edibles, and I believe they are processed in the liver? Is there any method of consumption that either bypasses the liver or would cause the least amount of damage. Alcohol has well-documented negative effects on the liver. Eating edibles get processed through your liver. It's a thing, having to do with liver enzymes or whatever, that some people just don't have success with the standard production of edibles. I love edibles after something greasy like fried foods! Your liver has to metabolize the thc and your liver is also metabolizing the oil! In theory, my theory anyway, the oily food helps carry some of the thc to your liver faster and more of it over time, thereby making you higher and higher longer ! THC gets converted by your liver after you ingest edibles into 11-hydroxy-THC (i think). Even gummies. Ive stopped smoking and switched to edibles so my lungs can rest. Someone has linked to this thread from another place on reddit: [r/marijuana] Edibles and Liver Function Edibles and Liver Function If you follow any of the above links, please respect the rules of reddit and don't vote in the other threads. That was my first experience with edibles back in the 1900's. . Edibles do hit harder than smoking excluding certain people who don’t feel edibles at all. For future reference, the amount you smoke/dab/vape has zero bearing on your tolerance to edibles. I know many of you are like this. This can be used for energy production or turned into fat. My lady friend can get high from smoking and vaping, but she can eat edibles all day and not feel a thing. 7 grams of weed and 3 grams of bubble hash mixed into a single stick of butter mixed straight I have a fatty liver from too much alcohol. Yeah been eating 8s the past few days, actually better than most 9 edibles i’ve had for me. Consuming edibles can result in more potent and prolonged effects, as the liver converts THC into a more potent metabolite, 11-hydroxy-THC. My wife smokes daily and ~5mg edible (half a gummy) has her nearly non functional, where I have to take 2. I eat edibles from 2-6 times Taking edibles and eating fatty food is a sure fire way to end up with your pants off 🤣 maybe try close to 25-50mg of edibles next time… some people need 100-200mg, all depends 🤷♂️ I prefer smoking, it’s instant and easier to control my intake. biggest difference is timing. It's not really a cannabis issue it's a liver issue buddy. With edibles, there is ensuring they are made properly, stomach acid, the condition of your liver, the efficiency of your intestines in absorbing, what you've eaten with the dose, all kinds off stuff. 5mg or 5mg edibles. It might be a problem with liver metabolism/first pass. Some people get blasted from a low dose and some people literally can't get high of em at all, everyone's liver is different. After seeing a lot of forums and speaking to one of my friends who is in the same boat I think it's possible some people don't get high of off edibles something to do with ur liver or that sort. The THC is metabolized in your liver before being dispersed into your bloodstream. i looked some stuff up and it seems like it probably doesn’t but i thought i would ask here Feb 23, 2021 · Bioavailability varies depending on the delivery method; CBD-only edibles tend to be less bioavailabile than THC edibles because CBD breaks down in the liver and becomes less potent. One time I got a mild buzz from 75mg THC, and that was when I ate the edible 45min after a huge meal. It might be the lack of an enzyme that helps digest it. The thing people are saying about the liver is that genetic or a result of poor liver health? My brothers dont get jack shit out of em but ive been on a liver cleanse on and off the past 2 years wonder if thats why they feel exactly the same as 9s to me? Aug 27, 2019 · We describe the current understandings of how cannabis is metabolized in the liver and its potential interactions with other common drugs. But if you're comparing a 50mg edible to a 50mg tincture dropper, then the potency is equal (with the tincture being much more bioavailable, albeit with a shorter duration, than the edible). If I took an edible within the past few days and take an edible it will be a greatly reduced experience and if it is strong it will be strong in a very groggy/sleepy way, not the normal medicated state. Has anybody else started partaking after already having fatty liver? Did it help/hurt/make no difference? I then switched to combo thc cbd edibles. I took a 100 mg edible last night, and after it had taken effect I consumed a larger than average amount of food. Cannabis, Vape VS Edible: The reason why vaped and edibles are different is mainly due to edibles making use of the liver to break down cannabinoids into cannabinoids that vaping does not create such as THC11 (11-hydroxy-THC) as a single example. If your bloodwork is good, and you're an occasional recreational user, you're probably fine. I'm gonna see if my friend can run to the dispensary for edibles for me or just take some ABV bud. I am just like you I smoke and dab daily but if I eat too many mgs, I will definitely not be happy. From MMJ to munchies, from nugs to news, and everything between! The casual cannabis community Jan 5, 2024 · Edible marijuana products, such as cannabis-infused foods and beverages, are processed differently by the liver compared to inhaled forms. Recipes for cannabis edibles. Mine was 32. I actually tried this form of THC in the hopes it would override the liver enzyme issue or whatever, but unfortunately, I feel no more high than if I had taken the same amount of a regular edible. They help increase the enzymes in the liver supposedly, or maybe the gut. If i don’t eat shortly after, the experience will be more mild or the onset will be delayed until I eat. Some individuals have really good enzymatic production and in turn, make efficient use of edibles. Liver enzymes convert some THC into its more potent form, 11-hydroxy-THC, which is then circulated throughout the body, interacting directly with our endocannabinoid system , producing I know the liver has to process oral/edible thc and cbd and so I’m wondering if anyone knows whether combining them with alcohol (which obviously also goes through the liver) could over-tax the liver and result in an inability to properly process both of them? I’ve been seeing mention of the potential of liver damage from edibles, including CBD oil. With edibles, it's not really a matter of "tolerance", it's just that different people are born with different genes and therefore make different amounts of the enzymes that help your liver process edibles. I can dab and get more higher. (Info / ^Contact) The author goes on to point out the warning on Epidiolex packaging that there is a risk for liver injury because 5-20% of patients in recent clinical trials experienced elevated liver enzymes. No, cannabis edibles don’t appear to be as harmful to the liver as alcohol is. Business, Economics, and Finance. First and foremost. Also even if they do produce the enzyme, if they don't eat something with fat ,the liver doesn't metabolize it as well as if they did. If the THC has already been decarboxylated, and it's been made into an edible, than nothing else should matter. Now when my liver is doing that it puts my seizure medication on the back burner possibly causing my levels to drop. Hell yeah, if the unlicensed "candy brand" edibles don't give a rat's ass about trademark law, of course they're also going to scam their customers. Eating a little fatty meal like a couple pizza slices 30 mins before you dose will get your liver processing things so that when you take your thc less will be wasted by your liver and there will be fat in your belly to help your body Absorb better. The reason pre loading fat helps is to bypass the first pass effect. Not to discourage you from trying edibles, but this may be a potential road block. The suggested dose for starting edible use is 10 milligrams of THC. Soy lechiten in edibles helps a lot too. A subreddit for all cannabis extracts - hash, oil, shatter, rosin, tincture, etc - and the people that enjoy them. There’s a theory (and I’ve found this true anecdotally) that these people lack the necessary enzymes to process the edibles through the liver. How edibles effect you really comes down more to how your body processes the THC, some people get virtually no effect from edibles while others can be to the moon off 10 mg. When edibles are ingested they must pass through the liver to the bloodstream. I have taken over 2,000 mg edibles with no effects. Dec 30, 2023 · “No. Hello all, I recently had some blood work done last week and my liver enzymes were off the charts. Now let's go back in time. Aug 7, 2023 · Edible cannabis products are known for their strong effects and long experience durations. Instead, the liver metabolizes edibles more slowly into a very potent 11-hydroxy-THC. When eating edibles, the liver metabolizes THC into a stronger compound than the brain normally receives from smoking. So some people get a more powerful effect from smoking, while others get a more powerful effect from edibles. On top of that, edibles are inconsistent in their concentration of active ingredients which makes accidental overdosing easier too. Later some is metabolized through the liver but less. Generally rule is low and slow. What we see is that people have damaged colonies and as a result can’t effectively absorb cannabis products through their liver. Eat your edible. In an effort to ditch smoking weed I exclusively only ate edibles this summer, 50-150mg a day and occasionally I’ll do a superhero dose around 300mg. Go on amazon. This according to Joe Rogan, whom I trust about this subject. Most homemade or baked good edibles will often be made with canna butter or oil, which is old school extraction style, decarbing and infusion. Edibles mess up my digestive tract something fierce. Your liver metabolizes thc into 11-hydroxy-thc when you eat it which is more potent Reply reply More replies More replies Eating an edible results in the thc being converted by the liver into a similar, but different form that has subjectively different effects (I’ve heard people describe it as both more body-oriented and a bit psychedelic). Her instructions were "eat it and wait a bit" I ate it and waited what I thought was a bit and I didn't feel anything. My question to yall the beautiful people on this reddit, how can get the same level as people does with edibles. Most edibles are made with distillate (pure thc extract) so our colony of enzymes only have to break down one specific type of cannabinoid when ingesting most edibles and if someone’s colony is damaged they may Edibles go thru your liver just like many epilepsy medications. leozaxr clavh qtpg khdv ndg ssqrl qtlub kjr ngqwo nhw